A CDK4 and CaMKII inhibitor (IC50s = 140 and 25 nM

Arcyriaflavin A – 1 mg

Brand:
Cayman
CAS:
118458-54-1
Storage:
-20
UN-No:
Non-Hazardous - /

Arcyriaflavin A is an inhibitor of cyclin-dependent kinase 4 (CDK4; IC50 = 140 nM) and calcium/calmodulin-dependent protein kinase II (CaMKII; IC50 = 25 nM).{38695} It is selective for CDK4 and CaMKII over protein kinase A (PKA) and PKC (IC50s = >2 and >100 µM, respectively). In vitro, arcyriaflavin A inhibits replication of human cytomegalovirus (HCMV; IC50 = 200 nM), as well as proliferation of HCT116 and NCI H460 human carcinoma cells (IC50s = 850 and 590 nM, respectively).{38695,38696} It also inhibits proliferation and induces apoptosis of endometriotic cyst stromal cells (ECSCs).{38699}  

 

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Description

A CDK4 and CaMKII inhibitor (IC50s = 140 and 25 nM, respectively); selective for CDK4 and CaMKII over PKA and PKC (IC50s = >2 and >100 µM, respectively); inhibits replication of HCMV in vitro (IC50 = 200 nM); inhibits proliferation of HCT116 and NCI H460 carcinoma cells in vitro (IC50s = 850 and 590 nM, respectively); inhibits proliferation and induces apoptosis of ECSCs

Formal name: 12,13-dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione

Synonyms: 

Molecular weight: 325.3

CAS: 118458-54-1

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Antivirals||Product Type|Biochemicals|Kinase Inhibitors|CaMKs||Product Type|Biochemicals|Kinase Inhibitors|CDKs||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Cycle||Research Area|Cancer|Cell Signaling|CaMK Signaling||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Viral Diseases

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