Antigen: human ARC amino acids 191-208 • Host: rabbit • Cross Reactivity: (+) human and mouse ARC • Application(s): IP and WB • ARC interacts with caspase-2 and -8 and inhibits enzymatic activity of caspase-8. ARC suppresses apoptosis induced by cell death adapters FADD and TRADD and by cell death receptors Fas

ARC Polyclonal Antibody – 1 ea

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Cayman
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Apoptosis is regulated by death domain (DD) and/or caspase recruitment domain (CARD) containing molecules and a caspase family of proteases. CARD domain-containing cell death regulators included RAIDD, Apaf-1, caspase-9, and caspase-2. A novel CARD domain containing protein was recently identified and designated ARC for apoptosis repressor with CARD.{7140} ARC interacts with caspase-2 and -8 and inhibits enzymatic activity of caspase-8. ARC suppresses apoptosis induced by cell death adapters FADD and TRADD and by cell death receptors Fas, TNFR-1 and DR3. The mRNA for ARC is expressed primarily in skeletal muscle and cardiac tissues.{7140}  

 

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SKU: 160737 - 1 ea Category:

Description

Antigen: human ARC amino acids 191-208 • Host: rabbit • Cross Reactivity: (+) human and mouse ARC • Application(s): IP and WB • ARC interacts with caspase-2 and -8 and inhibits enzymatic activity of caspase-8. ARC suppresses apoptosis induced by cell death adapters FADD and TRADD and by cell death receptors Fas, TNFR-1, and DR3.

Synonyms: Apoptosis Repressor with CARD

Immunogen: Synthetic peptide from the C-terminal region of human ARC

Formulation: 500 µl of Peptide affinity-purified polyclonal antibody

Isotype:

Applications: IP and WB

Origin: Animal/Rabbit

Stability: 365 days

Application|Immunoprecipitation||Application|Western Blot||Product Type|Antibodies|Polyclonal Antibodies||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cell Biology|Cell Death|Apoptosis||Research Area|Cell Biology|Proteolysis|Cytosolic & Secreted Proteases

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