A fatty acid bile acid conjugate; reduces ex vivo cholesterol crystallization in native human bile and dissolves pre-formed cholesterol crystals in a dose-dependent manner; completely prevents the formation of cholesterol crystals and gallstones in mice fed a lithogenic

Aramchol – 10 mg

Brand:
Cayman
CAS:
246529-22-6
Storage:
-20
UN-No:
Non-Hazardous - /

Aramchol, also known as arachidyl amido cholanoic acid, is a conjugate of arachidic acid (Item No. 9000339) and cholic acid (Item No. 20250).{38185} It reduces ex vivo cholesterol crystallization in native human bile and dissolves pre-formed cholesterol crystals in a dose-dependent manner. In vivo, aramchol completely prevents the formation of cholesterol crystals and gallstones in mice fed a lithogenic, high-fat diet. It also prevents lithogenic, high-fat diet-induced fatty liver in mice, rats, and hamsters.{38186} Formulations containing aramchol have been investigated clinically for the treatment of non-alcoholic fatty liver disease (NAFLD).{38187}  

 

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Description

A fatty acid bile acid conjugate; reduces ex vivo cholesterol crystallization in native human bile and dissolves pre-formed cholesterol crystals in a dose-dependent manner; completely prevents the formation of cholesterol crystals and gallstones in mice fed a lithogenic, high-fat diet; prevents lithogenic, high-fat diet-induced fatty liver in mice, rats, and hamsters,

Formal name: (3β,5β,7α,12α)-7,12-dihydroxy-3-[(1-oxoeicosyl)amino]-cholan-24-oic acid

Synonyms:  Arachidyl Amido Cholanoic Acid

Molecular weight: 702.1

CAS: 246529-22-6

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Lipids|Sterol Lipids||Research Area|Endocrinology & Metabolism|Bile Acids & Microbiome||Research Area|Endocrinology & Metabolism|Metabolic Diseases|NAFLD & NASH||Research Area|Lipid Biochemistry|Sterol Lipids

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