Arachidonamide is an analog of AEA that lacks the hydroxyethyl moiety. It is hydrolyzed by FAAH more effectively than AEA but exhibits significantly weaker binding to the human CB1 receptor with a Ki value of 9.6 µM. Arachidonamide and AEA exhibit similar binding and translocation into cells via the AEA transporter. Arachidonamide inhibits [3H]-AEA uptake into human astrocytoma cells with an IC50 value of 9 µM and inhibits rat glial gap junction cell-cell communication by 90% at a concentration of 20 µM.

Arachidonoyl amide – 50 mg

Brand:
Cayman
CAS:
85146-53-8
Storage:
-20
UN-No:
Excepted Quantity - 1231 / 3

Anandamide (AEA) is an endogenous cannabinoid that binds to both central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptors. The biological actions of AEA are terminated by cellular uptake and hydrolysis of the amide bond by the enzyme fatty acid amide hydrolase (FAAH). Arachidonoyl amide is an analog of anandamide (AEA) that lacks the hydroxyethyl moiety. It is hydrolyzed by FAAH more effectively than AEA but exhibits significantly weaker binding to the human CB1 receptor with a Ki of 9.6 µM.{2713,13257} Arachidonoyl amide and AEA exhibit similar binding and translocation into cells via the AEA transporter. It inhibits [3H]-AEA uptake into human astrocytoma cells with an IC50 of 9 µM.{13757} Arachidonoyl amide also inhibits rat glial gap junction cell-cell communication by 90% at a concentration of 20 µM.{8122}  

 

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SKU: 10007295 - 50 mg Category:

Description

Arachidonamide is an analog of AEA that lacks the hydroxyethyl moiety. It is hydrolyzed by FAAH more effectively than AEA but exhibits significantly weaker binding to the human CB1 receptor with a Ki value of 9.6 µM. Arachidonamide and AEA exhibit similar binding and translocation into cells via the AEA transporter. Arachidonamide inhibits [3H]-AEA uptake into human astrocytoma cells with an IC50 value of 9 µM and inhibits rat glial gap junction cell-cell communication by 90% at a concentration of 20 µM.

Formal name: 5Z,8Z,11Z,14Z-eicosatetraenamide

Synonyms:  Arachidonamide|Arachidonic Acid amide

Molecular weight: 303.5

CAS: 85146-53-8

Purity: >98%

Formulation: A solution in methyl acetate

Product Type|Biochemicals|Lipids|Fatty Amides||Product Type|Biochemicals|Receptor Pharmacology||Research Area|Lipid Biochemistry|Endocannabinoid/Endocannabinoid-like||Research Area|Lipid Biochemistry|Lipid Transport||Research Area|Neuroscience|Cannabinoid Research|CB1 & CB2 Receptors||Research Area|Neuroscience|Cannabinoid Research|Endocannabinoids

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