An anticancer nucleoside analog; an active metabolite of nelarabine; accumulates in T lymphoblasts and malignant T-lymphoid cells

Ara-G – 250 mg

Brand:
Cayman
CAS:
38819-10-2
Storage:
-20
UN-No:
Non-Hazardous - /

Ara-G is an analog of the nucleoside guanosine and an active metabolite of nelarabine (Item No. 20248).{47551,47552} Ara-G accumulates in T lymphoblasts and malignant T-lymphoid cells, where it is phosphorylated to produce ara-GTP and incorporated into the DNA.{32256,47551} Ara-G inhibits DNA replication by 92% after 30 minutes when used at a concentration of 50 µM in CEM cells, which are used as a model for human T lymphoblasts.{47551} It also halts the cell cycle at the sub-G1 phase and induces apoptosis in CEM cells.{32256} Syngeneic bone marrow containing 6C3HED tumor cells treated with ara-G (100 mM) ex vivo prior to transplantation increases survival of lethally irradiated mice and induces reconstitution of lymphoid, myeloid, and erythroid cell linages.{47553}  

 

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SKU: 27984 - 250 mg Category:

Description

An anticancer nucleoside analog; an active metabolite of nelarabine; accumulates in T lymphoblasts and malignant T-lymphoid cells, where it is phosphorylated to produce ara-GTP and incorporated into the DNA; inhibits DNA replication by 92% after 30 minutes at 50 µM in CEM cells; increases survival of lethally irradiated mice and induces reconstitution of lymphoid, myeloid, and erythroid cell linages when used at 100 mM to treat syngeneic bone marrow at containing 6C3HED tumor cells ex vivo prior to transplantation

Formal name: 2-amino-9-β-D-arabinofuranosyl-1,9-dihydro-6H-purin-6-one

Synonyms:  ara-Guanosine|Guanine Arabinoside|NSC 76352

Molecular weight: 283.2

CAS: 38819-10-2

Purity: ≥95%

Formulation: A solid

Product Type|Biochemicals|Nucleotides/Nucleosides||Product Type|Biochemicals|Small Molecule Inhibitors|Nucleic Acid Turnover/Signaling||Product Type|Biochemicals|Xenobiotic Metabolites||Research Area|Cancer|Cell Cycle|G1||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|DNA Damage and Repair||Research Area|Toxicology|Drug Metabolism|Drug Metabolites

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