A selective agonist of FFAR3 (IC50 = 117 nM) that does not activate the related receptor FFAR2 at concentrations up to 100 µM; 10 µM stimulates a 1.26-fold increased release of glucagon-like peptide-1 from colonic crypt cultures

AR420626 – 500 µg

Brand:
Cayman
CAS:
1798310-55-0
Storage:
-20
UN-No:
Non-Hazardous - /

Free fatty acid receptor 3 (FFAR3; GPR41) is a G protein-coupled receptor activated by short chain fatty acids (SCFAs). It is expressed in adipose tissue, the gastrointestinal tract, and the peripheral nervous system, and it is involved in SCFA-dependent energy regulation.{28496} AR420626 is a selective agonist of FFAR3 (GPR41; IC50 = 117 nM) that does not activate the related receptor FFAR2 (GPR43) at concentrations up to 100 µM.{27420} At 10 µM, it can stimulate a 1.26-fold increased release of glucagon-like peptide-1 from colonic crypt cultures.{28497}  

 

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Description

A selective agonist of FFAR3 (IC50 = 117 nM) that does not activate the related receptor FFAR2 at concentrations up to 100 µM; 10 µM stimulates a 1.26-fold increased release of glucagon-like peptide-1 from colonic crypt cultures

Formal name: ​N-(2,5-dichlorophenyl)-4-(2-furanyl)-1,4,5,6,7,8-hexahydro-2-methyl-5-oxo-3-quinolinecarboxamide

Synonyms: 

Molecular weight: 417.3

CAS: 1798310-55-0

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Endocrinology & Metabolism|Carbohydrate Metabolism

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