A RARα antagonist; increases chaperone-mediated autophagy in an RARα-dependent manner

AR-7 – 5 mg

Brand:
Cayman
CAS:
80306-38-3
Storage:
-20
UN-No:
Non-Hazardous - /

AR-7 is a retinoic acid receptor α (RARα) antagonist.{45302} In mouse fibroblasts, AR-7 (20 μM) increases chaperone-mediated autophagy in an RARα-dependent manner, increases LAMP-2A expression, and inhibits paraquat-induced decreases in cell viability. AR-7 is also selectively cytotoxic to HepG2 cells grown under hypoxic over normoxic conditions (IC50s = 10 and >1,000 μM, respectively).{45303}  

 

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SKU: 22946 - 5 mg Category:

Description

A RARα antagonist; increases chaperone-mediated autophagy in an RARα-dependent manner, increases LAMP-2A expression, and inhibits paraquat-induced decreases in cell viability in mouse fibroblasts at 20 μM; selectively cytotoxic to HepG2 cells grown under hypoxic over normoxic conditions (IC50s = 10 and >1,000 μM, respectively)

Formal name: 7-chloro-3-(4-methylphenyl)-2H-1,4-benzoxazine

Synonyms: 

Molecular weight: 257.7

CAS: 80306-38-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Cancer|Cell Death||Research Area|Cancer|Tumor Microenvironment||Research Area|Cell Biology|Cellular Chaperones||Research Area|Cell Biology|Endomembrane System & Vesicular Trafficking|Autophagy||Research Area|Endocrinology & Metabolism|Hormones & Receptors|RARs, RORs, & RXRs

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