An inhibitor of Hsp70 (65% inhibition at 200 µM) that acts by blocking its ATPase activity; induces apoptosis in cancer cells (IC50 = 5-7 µM); prevents the growth of A549

Apoptozole – 10 mg

Brand:
Cayman
CAS:
1054543-47-3
Storage:
-20
UN-No:
Non-Hazardous - /

Apoptozole is an inhibitor of heat shock protein 70 (Hsp70; 65% inhibition at 200 µM) that acts by blocking its ATPase activity.{28548} It does not act on Hsp40, Hsp60, or Hsp90. Apoptozole dose-dependently induces apoptosis in cancer cells (IC50 = 5-7 µM).{28548} It prevents the association of Hsp70 with apoptotic protease-activating factor 1 and triggers caspase activation in HeLa cells.{28548} Apoptozole (10 mg/kg, i.p.) prevents the growth of A549, RKO, and HeLa cell xenografts in mice without significant loss of body weight.{28545}  

 

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Description

An inhibitor of Hsp70 (65% inhibition at 200 µM) that acts by blocking its ATPase activity; induces apoptosis in cancer cells (IC50 = 5-7 µM); prevents the growth of A549, RKO, and HeLa cell xenografts in mice without significant loss of body weight

Formal name: 4-[[2-[3,5-bis(trifluoromethyl)phenyl]-4,5-bis(4-methoxyphenyl)-1H-imidazol-1-yl]methyl]-benzamide

Synonyms:  Apoptosis Activator VII

Molecular weight: 625.6

CAS: 1054543-47-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Heat Shock Proteins||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cell Biology|Cellular Chaperones

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