An apoptosis inducer that inhibits the mitochondrial F1FO ATPase (Ki = 4-5 µM); selectively kills transformed glial cells without significantly affecting untransformed cells

Apoptolidin – 100 µg

Brand:
Cayman
CAS:
194874-06-1
Storage:
-20
UN-No:
Non-Hazardous - /

Apoptolidin is an apoptosis inducer originally isolated from Nocardiopsis bacteria.{31038} It inhibits the mitochondrial F1FO ATPase (Ki = 4-5 µM).{31039,20629} Apoptolidin selectively kills transformed glial cells without significantly affecting untransformed cells.{20629} It also has antibiotic and antifungal actions.{31038,20629}  

 

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Description

An apoptosis inducer that inhibits the mitochondrial F1FO ATPase (Ki = 4-5 µM); selectively kills transformed glial cells without significantly affecting untransformed cells

Formal name: (1R)-O-2,6-dideoxy-3-O-methyl-β-D-arabino-hexopyranosyl-(1→4)-O-2,6-dideoxy-3-C-methyl-α-L-arabino-hexopyranosyl-(1→8)-3,5,7-trideoxy-1-C-[(2S,4S,5S,8E,10E,12R,13R,14E,16E,18E)-12-[(6-deoxy-4-O-methyl-α-L-glucopyranosyl)oxy]-5-hydroxy-4-methoxy-9,13,15,17,19-pentamethyl-20-oxooxacycloeicosa-8,10,14,16,18-pentaen-2-yl]-3,5-dimethyl-9-O-methyl-L-glycero-α-D-galacto-2-nonulopyranose

Synonyms:  Apoptolidin A

Molecular weight: 1,129.40

CAS: 194874-06-1

Purity: ≥95%

Formulation: A lyophilisate

Product Type|Biochemicals|Antibiotics||Product Type|Biochemicals|Antifungals||Product Type|Biochemicals|Natural Products|Microbial Metabolites||Product Type|Biochemicals|Small Molecule Inhibitors|ATPases||Product Type|Biochemicals|Transporter & Exchanger Modulators||Research Area|Cell Biology|Cell Death|Apoptosis||Research Area|Cell Biology|Mitochondrial Biology

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