An inhibitor of Factor Xa (Kis = 0.8 nM for free and prothrombinase-bound enzyme

Apixaban – 50 mg

Brand:
Cayman
CAS:
503612-47-3
Storage:
-20
UN-No:
Non-Hazardous - /

Apixaban is an orally bioavailable, selective inhibitor of both free and prothrombinase-bound factor Xa (Kis = 0.8 nM).{25094} In vivo, apixaban has antithrombotic effects in a rabbit model of venous thrombosis. Apixaban (357.5 mg) also prevents thrombus formation without inducing adverse bleeding events in a porcine model of aortic heterotopic valve replacement.{36697} Formulations containing apixaban have been used to prevent blood clot formation in patients with atrial fibrillation.  

 

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Description

An inhibitor of Factor Xa (Kis = 0.8 nM for free and prothrombinase-bound enzyme, respectively); has antithrombotic effects in a rabbit model of venous thrombosis; prevents thrombus formation without inducing adverse bleeding events in a porcine model of aortic heterotopic valve replacement

Formal name: 4,5,6,7-tetrahydro-1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxo-1-piperidinyl)phenyl]-1H-pyrazolo[3,4-c]pyridine-3-carboxamide

Synonyms:  BMS 562247-01

Molecular weight: 459.5

CAS: 503612-47-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Blood Coagulation Factors||Research Area|Cardiovascular System|Blood|Acute Phase Reactants||Research Area|Cardiovascular System|Blood|Thrombosis||Research Area|Cardiovascular System|Heart|Arrhythmia

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