An internal standard for the quantification of apigenin by GC- or LC-MS

Apigenin-d5 – 1 mg

Brand:
Cayman
CAS:
263711-74-6
Storage:
-20
UN-No:
Non-Hazardous - /

Apigenin-d5 is an internal standard for the quantificaiton of apigenin (Item No. 10010275) by GC- or LC-MS. Apigenin is a flavonoid compound found in many fruits and vegetables that selectively inhibits casein kinase 2 (CK2). Apigenin inhibits CK2 activity in the renal cortex with an IC50 value of 30 µM to improve renal function in a rat model of glomerulonephritis.{15364} CK2 inhibition by 20 µM apigenin decreases the degradation of IκBα and down-regulates NF-κB levels in WEHI-231 cells.{15361} Apigenin, at 5 µM, is a potent inhibitor of the synthesis of the inflammatory mediators nitric oxide and prostaglandin E2, reducing inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) expression by 56% and 64%, respectively, in the macrophage cell line J774A.1.{15362}  

 

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Description

An internal standard for the quantification of apigenin by GC- or LC-MS,

Formal name: 5,7-dihydroxy-2-(4-hydroxyphenyl-3,5-d2)-4H-1-benzopyran-4-one-3,6,8-d3

Synonyms:  [3,6,8,3’,5’-d5]-Apigenin|Chamomile-d5|Flavone-d5|Versulin-d5

Molecular weight: 275.3

CAS: 263711-74-6

Purity: ≥99% deuterated forms (d1-d5); ≤1% d0

Formulation: A solid

Application|Mass Spectrometry||Product Type|Biochemicals|Isotopically Labeled Standards|Deuterium||Product Type|Biochemicals|Kinase Inhibitors|CK2||Product Type|Biochemicals|Natural Products|Flavonoids||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cell Biology|Cell Signaling|NF-κB Signaling||Research Area|Epigenetics, Transcription, & Translation|Transcription Factors||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Prostaglandins||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Lipid Biochemistry|Cyclooxygenase Pathway

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