A natural tetracyclic diterpene with antiviral activity against herpes simplex; a cell-permeable

(+)-Aphidicolin – 5 mg

Brand:
Cayman
CAS:
38966-21-1
Storage:
-20
UN-No:
Non-Hazardous - /

(+)-Aphidicolin is a natural tetracyclic diterpene first isolated from the fungus C. aphidicola and shown to have antiviral activity against herpes simplex.{22496} In eukaryotic cells, it is a cell-permeable, reversible inhibitor of DNA replication, specifically blocking the activity of DNA polymerases α, δ, and ε when used at low micromolar levels.{22501,22499,22497} Aphidicolin can be used, at 3 μM, to arrest cells in G1/S phase or to increase gene amplification frequency.{22498,22502}  

 

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Description

A natural tetracyclic diterpene with antiviral activity against herpes simplex; a cell-permeable, reversible inhibitor of DNA replication in eukaryotic cells, specifically blocking the activity of DNA polymerases α, δ, and ε when used at low micromolar levels.

Formal name: (3R,4R,4aR,6aS,8R,9R,11aS,11bS)-tetradecahydro-3,9-dihydroxy-4,11b-dimethyl-8,11a-methano-11aH-cyclohepta[a]naphthalene-4,9-dimethanol

Synonyms:  ICI 69653|NSC 234714

Molecular weight: 338.5

CAS: 38966-21-1

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Antivirals||Product Type|Biochemicals|Natural Products|Microbial Metabolites||Product Type|Biochemicals|Natural Products|Terpenes||Product Type|Biochemicals|Small Molecule Inhibitors|Nucleic Acid Turnover/Signaling||Research Area|Cell Biology|Cell Cycle||Research Area|Epigenetics, Transcription, & Translation|RNA, DNA, & Protein Synthesis||Research Area|Infectious Disease|Viral Diseases|HSV

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