An inhibitor of APC/C; competitively binds to Cdc20 and prevents substrate interaction and ubiquitylation; halts mitosis; works synergistically with TAME and proTAME to halt cells in mitosis; works synergistically with proTAME to increase apoptosis in multiple myeloma cells

Apcin – 1 mg

Brand:
Cayman
CAS:
300815-04-7
Storage:
-20
UN-No:
Non-Hazardous - /

Apcin is an inhibitor of the E3 ligase activity of the mitotic anaphase-promoting complex/cyclosome (APC/C). Apcin competitively binds to Cdc20 and prevents substrate interaction and ubiquitylation required for continuation of mitosis.{36287} Apcin enhances the effect of the APC/C inhibitor N-4-tosyl-L-arginine methyl ester (TAME; Item No. 17550) and its prodrug, proTAME, leading to an increase in the number of cells in mitosis, a longer mitotic duration, and greater stabilization of cyclin B1, cycB1-NT, securin, and cyclin A2.{36287} Apcin, in combination with proTAME, synergistically increases apoptosis in multiple myeloma cells.{36286}  

 

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Description

An inhibitor of APC/C; competitively binds to Cdc20 and prevents substrate interaction and ubiquitylation; halts mitosis; works synergistically with TAME and proTAME to halt cells in mitosis; works synergistically with proTAME to increase apoptosis in multiple myeloma cells

Formal name: [2,2,2-trichloro-1-(2-pyrimidinylamino)ethyl]-carbamic acid, 2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl ester

Synonyms: 

Molecular weight: 438.7

CAS: 300815-04-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Ubiquitin Ligase System||Research Area|Cancer|Cell Cycle|G2/M||Research Area|Cancer|Cell Death|Apoptosis

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