A potent blocker of small conductance Ca2+-activated K+ (SK

Apamin (trifluoroacetate salt) – 500 µg

Brand:
Cayman
CAS:
24345-16-2
Storage:
-20
UN-No:
Non-Hazardous - /

Apamin is an 18 amino acid peptide toxin found in bee venom. It is a potent blocker of small conductance Ca2+-activated K+ (SK, KCa2) channels that is more effective at SK2 than SK1 and SK3 (IC50 values are 0.06-0.4, 1-12, and 1-13 nM, respectively).{27792,27794} It is ineffective against SK4 at 1 µM.{27794} Apamin is used to elucidate the roles of these channels in cells and tissues expressing SK channels, including neurons, vascular endothelium, bladder smooth muscle, and certain types of cancer cells.{27791,27789,27790,27793}  

 

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Description

A potent blocker of small conductance Ca2+-activated K+ (SK, KCa2) channels that is more effective at SK2 than SK1 and SK3 (IC50 values are 0.06-0.4, 1-12, and 1-13 nM, respectively); ineffective against SK4 at 1 µM

Formal name: L-cysteinyl-L-asparaginyl-L-cysteinyl-L-lysyl-L-alanyl-L-prolyl-L-α-glutamyl-L-threonyl-L-alanyl-L-leucyl-L-cysteinyl-L-alanyl-L-arginyl-L-arginyl-L-cysteinyl-L-glutaminyl-L-glutaminyl-L-histidinamide, cyclic (1→11),(3→15)-bis(disulfide), trifluoroacetate salt

Synonyms:  Ro 23-6721

Molecular weight: 2,027.30

CAS: 24345-16-2

Purity: ≥95%

Formulation: A solid

Product Type|Biochemicals|Ion Channel Modulation|Blockers||Product Type|Biochemicals|Natural Products||Product Type|Biochemicals|Peptides||Research Area|Cancer||Research Area|Cardiovascular System|Vasculature|Endothelium||Research Area|Neuroscience

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