A compound used to increase the levels of H2S within mitochondria; stimulates mitochondrial electron transport and improves cellular bioenergetic function at lower concentrations (30-100 nM)

AP39 – 25 mg

Brand:
Cayman
CAS:
1429173-57-8
Storage:
-20
UN-No:
De Minimis - 1593 / 6.1

AP39 is a compound used to increase the levels of hydrogen sulfide (H2S) within mitochondria.{28632} It consists of a mitochondria-targeting motif (triphenylphosphonium) coupled to an H2S-donating moiety (dithiolethione) by an aliphatic linker. AP39 (30-300 nM) dose-dependently increases H2S levels in endothelial cells, predominantly in mitochondrial regions.{28632} It stimulates mitochondrial electron transport and improves cellular bioenergetic function at lower concentrations (30-100 nM), while having an inhibitory effect at 300 nM.{28632} Under oxidative stress conditions induced by glucose oxidase, AP39 has antioxidant and cytoprotective effects.{28632} AP39 is effective in vivo, inhibiting voltage-dependent T-type calcium channels and improving hemodynamic parameters in rats.{28633}  

 

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Description

A compound used to increase the levels of H2S within mitochondria; stimulates mitochondrial electron transport and improves cellular bioenergetic function at lower concentrations (30-100 nM), while having an inhibitory effect at 300 nM; is effective in vivo

Formal name: [10-oxo-10-[4-(3-thioxo-3H-1,2-dithiol-5-yl)phenoxy]decyl]triphenyl-phosphonium

Synonyms: 

Molecular weight: 641.9

CAS: 1429173-57-8

Purity: ≥95%

Formulation: A solution in dichloromethane

Product Type|Biochemicals|Ion Channel Modulation|Blockers||Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Product Type|Biochemicals|Ox Stress Reagents|Hydrogen Sulfide Donors||Research Area|Cardiovascular System|Heart||Research Area|Cell Biology|Mitochondrial Biology||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|Reactive Sulfur|H2S

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