A small molecule enolase inhibitor (IC50 = 0.576 µM)

AP-III-a4 – 10 mg

Brand:
Cayman
CAS:
1177827-73-4
Storage:
-20
UN-No:
De Minimis - 3077 / 9

AP-III-a4 is a small molecule enolase inhibitor (IC50 = 0.576 µM) that inhibited cancer cell metastasis in an in vivo zebrafish cancer cell xenograft model.{34074} It also reduced hyperglycemia and hyperlipidemia in C57BL/Ksj-db/db mice, a transgenic model of type 2 diabetes.{34075} Another study found that AP-III-a4 did not directly block enolase activity in vitro and suggested the mechanism is indirect.{34076}  

 

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Description

A small molecule enolase inhibitor (IC50 = 0.576 µM),

Formal name: N-[2-[2-(2-aminoethoxy)ethoxy]ethyl]-4-[[4-[(cyclohexylmethyl)amino]-6-[[(4-fluorophenyl)methyl]amino]-1,3,5-triazin-2-yl]amino]-benzeneacetamide

Synonyms:  ENOblock

Molecular weight: 594.7

CAS: 1177827-73-4

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Cancer|Cell Migration & Metastasis||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Dyslipidemias

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