A component of the antimycin A antibiotic complex; more polar than antimycin A1 and A2 but not A4; inhibits mitochondrial respiration (IC50 = 38 nM); inhibits ATP-citrate lyase with a Ki value of 60.1 µM; stimulates the production of ROS

Antimycin A3 – 1 mg

Brand:
Cayman
CAS:
522-70-3
Storage:
-20
UN-No:
Non-Hazardous - /

Antimycin A3 is a component of the antimycin A antibiotic complex that is more polar than antimycin A1 (Item No. 19433) and antimycin A2 (Item No. 21997) but not antimycin A4 (Item No. 21999).{38029,38030,38028,35010} Antimycin A3 binds to the Q(inner) site of mitochondrial complex III (cytochrome bc1) and inhibits mitochondrial respiration (IC50 = 38 nM in isolated rat liver mitochondria).{35009} It also inhibits ATP-citrate lyase with a Ki value of 60.1 µM, and it stimulates the production of reactive oxygen species.{38027,35008} In molecular modeling studies, antimycin binds to a mutant form of Bcl-2 (hBcl-2Δ22) and has a Kd value of 0.82 µM for binding to a recombinant mutant form of Bcl-2 (rhBcl-2Δ22) in an isothermal calorimetry assay.{35007}  

 

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Description

A component of the antimycin A antibiotic complex; more polar than antimycin A1 and A2 but not A4; inhibits mitochondrial respiration (IC50 = 38 nM); inhibits ATP-citrate lyase with a Ki value of 60.1 µM; stimulates the production of ROS,

Formal name: 2(or 3)-methyl-butanoic acid, (2R,3S,6S,7R,8R)-3-[[3-(formylamino)-2-hydroxybenzoyl]amino]-8-butyl-2,6-dimethyl-4,9-dioxo-1,5-dioxonan-7-yl ester

Synonyms:  Blastomycin|NSC 58239

Molecular weight: 520.6

CAS: 522-70-3

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Antibiotics||Product Type|Biochemicals|Antifungals||Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Cell Biology|Mitochondrial Biology||Research Area|Oxidative Stress & Reactive Species|Pro-oxidant Activity||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen

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