A fungal metabolite; active against S. aureus

Antibiotic PF 1052 – 500 µg

Brand:
Cayman
CAS:
147317-15-5
Storage:
-20
UN-No:
Non-Hazardous - /

Antibiotic PF 1052 is a fungal metabolite originally isolated from Phoma.{48341,48342} It is active against S. aureus, S. parvulus, and C. perfringens (MICs = 3.13, 0.78, and 0.39 µg/ml, respectively), among others.{48341} It inhibits neutrophil migration in a wound assay using zebrafish larvae expressing GFP-labeled neutrophils, reducing pseudopodia formation and inducing rounding of neutrophils.{48342} Antibiotic PF 1052 is selective for neutrophil migration over macrophage migration in zebrafish larvae. It also inhibits the migration of murine neutrophils when used at concentrations of 10 and 20 µM.  

 

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SKU: 27743 - 500 µg Category:

Description

A fungal metabolite; active against S. aureus, S. parvulus, and C. perfringens (MICs = 3.13, 0.78, and 0.39 µg/ml, respectively), among others; inhibits neutrophil migration in a zebrafish larva wound assay, reducing pseudopodia formation and inducing rounding of neutrophils; inhibits murine neutrophil migration at 10 and 20 µM

Formal name: 3-[[2-(2,3-dimethyl-2-oxiranyl)-1,2,4a,5,6,7,8,8a-octahydro-6,8-dimethyl-1-naphthalenyl]hydroxymethylene]-1-methyl-5-(1-methylpropyl)-2,4-pyrrolidinedione

Synonyms: 

Molecular weight: 429.6

CAS: 147317-15-5

Purity: ≥95%

Formulation: A solid

Product Type|Biochemicals|Antibiotics||Product Type|Biochemicals|Natural Products|Microbial Metabolites||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases|Food-borne Illnesses

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