Description
The Anti-Inflammatory Screening Library consists of 3 plates and contains approximately 235 anti-inflammatory and related compounds in a 96-well Matrix™ tube rack format as 10 mM stock solutions in DMSO. This library includes inhibitors of pro-inflammatory cytokine production, macrophage and T cell activation, cytokine storm receptor signaling, the NLRP3 inflammasome, NF-κB signaling, and kinases involved in canonical and non-canonical inflammatory signaling pathways. It also includes corticosteroids, glucocorticoids, and inhibitors of enzymes involved in inflammatory lipid mediator production and metabolism, such as COX-1 and COX-2, 5-lipoxygenase (5-LO), microsomal prostaglandin E synthase-1 (mPGES-1), cytosolic phospholipase A2 (cPLA2), and soluble epoxide hydrolase (sEH). Additional targets include enzymes and receptors involved in NETosis, coagulation, and platelet aggregation. Please review the product insert for a full list of targets. Stability data is not available for the compounds as supplied in the screening library.
Synonyms:
Immunogen:
Formulation: A 10 mM solution in DMSO
Isotype:
Applications:
Origin:
Stability: 365 days
Application|High-Throughput Screening||Product Type|Biochemicals|Compound Libraries||Research Area|Cardiovascular System|Blood|Coagulation & Hemostasis||Research Area|Cardiovascular System|Blood|Thrombosis||Research Area|Cell Biology|Cell Signaling|NF-κB Signaling||Research Area|Endocrinology & Metabolism|Hormones & Receptors|Glucocorticoids & Mineralocorticoids||Research Area|Immunology & Inflammation|Adaptive Immunity||Research Area|Immunology & Inflammation|Immunosuppressants||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Leukotrienes||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Prostaglandins||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Specialized Pro-Resolving Mediators||Research Area|Immunology & Inflammation|Innate Immunity|NETosis||Research Area|Lipid Biochemistry|Cyclooxygenase Pathway||Research Area|Lipid Biochemistry|Cytochrome P450 Pathways||Research Area|Lipid Biochemistry|Glycerophospholipids|Phospholipases||Research Area|Lipid Biochemistry|Lipoxygenase Pathways
