Immunogen: Carbamylated protein • Clone designation: 1C6 • Host: Mouse • Species Reactivity: Species independent • Isotype: IgG1 • Applications: ELISA

Anti-Carbamylation (Homocitrulline) Monoclonal Antibody – 100 µg

Brand:
Cayman
Storage:

Carbamylation is a non-enzymatic and irreversible post-translational modification whereby cyanate reacts with lysine residues within polypeptide chains to generate ε-carbamyl-lysine (homocitrulline).{34533} Cyanate originates from the decomposition of urea and exists in equilibrium with its reactive form isocyanic acid.{34532} Neutrophil-derived MPO mediates the conversion of thiocyanate to isocyanate at sites of inflammation.{34533,34534} Increased levels of urea associated with chronic kidney disease result in elevated cyanate concentrations and a higher potential for carbamylated proteins.{34535} The presence of carbamylated proteins has been associated with rheumatoid arthritis.{34536} Homocitrulline residues are structurally similar to citrulline, the presence of an additional methylene group on homocitrulline being the only difference. Peptidylarginine deiminase (PAD)-catalyzed formation of citrulline residues on proteins and peptides can indicate many of the same disease states as the presence of homocitrulline residues. The ability to differentiate between citrullinated and carbamylated proteins has been difficult using traditional techniques. Cayman’s Anti-Carbamylation (Homocitrulline) Monoclonal Antibody specifically detects carbamylated proteins and does not detect the unmodified or citrullinated counterparts.  

 

Available on backorder

Add to quotes
SKU: 23203 - 100 µg Category:

Description

Immunogen: Carbamylated protein • Clone designation: 1C6 • Host: Mouse • Species Reactivity: Species independent • Isotype: IgG1 • Applications: ELISA, IP, WB

Synonyms:

Immunogen: Carbamylated protein

Formulation: 100 µg protein G-purified antibody

Isotype: IgG1

Applications: ELISA, IP, WB

Origin:

Stability: 365 days

Application|ELISA||Application|Immunoprecipitation||Application|Western Blot||Product Type|Antibodies|Monoclonal Antibodies||Research Area|Immunology & Inflammation|Autoimmunity|Rheumatoid Arthritis||Research Area|Oxidative Stress & Reactive Species|Protein Oxidation

Related products