Description
DNA methylation of cytosine to 5-methyl cytosine (5-mC) is an epigenetic mark that is relatively common in both plants and mammals and plays a role in transcriptional and chromatin regulation. In healthy cells, DNA methylation occurs at CpG sites, but CpG islands are generally not modified. However, tumor cells show an increase in CpG island methylation and a decrease in individual CpG sites.{27017} This ‘hypo-methylation’ can lead to aberrant activation of genes. Anti-5-methyl Cytosine Rabbit Monoclonal Antibody (Clone RM231) is a probe for immunochemical detection of 5-methyl cytosine by methylated DNA immunoprecipitation, IHC, ICC, ELISA, or dot blot.
Synonyms: 5-mC
Immunogen: BSA-conjugated 5-methyl cytosine
Formulation: 50 µg of protein A-affinity purified antibody
Isotype: IgG
Applications: Dot blot, ELISA, ICC, IHC, MeDIP
Origin:
Stability: 365 days
Application|ELISA||Application|Immunocytochemistry||Application|Immunohistochemistry||Application|Immunoprecipitation||Product Type|Antibodies|Monoclonal Antibodies||Research Area|Epigenetics, Transcription, & Translation|Writers|DNA/RNA Methylation
