An anthrone inhibitor of keratinocyte proliferation and a modulator of differentiation; increases apoptosis and inhibits proliferation of NHKs at 2.5 μM; decreases the mitochondrial membrane potential

Anthralin – 1 g

Brand:
Cayman
CAS:
1143-38-0
Storage:
-20
UN-No:
Non-Hazardous - /

Anthralin is an anthrone inhibitor of keratinocyte proliferation and a modulator of differentiation.{45558} It increases apoptosis and inhibits proliferation of normal human keratinocytes (NHKs) when used at a concentration of 2.5 μM. It also decreases the mitochondrial membrane potential, increases cytochrome c release, and induces perinuclear mitochondrial clustering in NHKs when used at a concentration of 5 μM.{45559} Anthralin (0.25 μM) decreases the expression of β-defensin-2 (Item No. 24577) and S100 calcium-binding protein A9 (S100A9) and increases the expression of IL-6 and IL-8 in IL-17A- and IL-22-stimulated NHKs.{45558} It also inhibits leukotriene B4 (LTB4; Item No. 20110) production, stimulated by the calcium ionophore A23187 (Item No. 11016), from human neutrophils (IC50 = 7 μM).{342} Topical anthralin (0.1%) induces hair regrowth in a Dundee experimental bald rat (DEBR) model of alopecia areata.{45560}  

 

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Description

An anthrone inhibitor of keratinocyte proliferation and a modulator of differentiation; increases apoptosis and inhibits proliferation of NHKs at 2.5 μM; decreases the mitochondrial membrane potential, increases cytochrome c release, and induces perinuclear mitochondrial clustering in NHKs at 5 μM; decreases β-defensin-2 and S100A9 expression and increases IL-6 and IL-8 expression in IL-17A- and IL-22-stimulated NHKs at 0.25 μM; inhibits A23187-stimulated LTB4 production from human neutrophils (IC50 = 7 μM); induces hair regrowth in a DEBR model of alopecia areata

Formal name: 1,8-dihydroxy-9(10H)-anthracenone

Synonyms:  1,8,9-Anthracenetriol|Dithranol|NSC 43970|NSC 629313

Molecular weight: 226.2

CAS: 1143-38-0

Purity: ≥90%

Formulation: A crystalline solid

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