An ansamycin antibiotic and antifungal; inhibits bone resorption (IC50 = 64 nM); inhibits pp60c-srcM kinase (IC50 = 100 nM); inhibits TNF-α-induced expression of ICAM-1 (IC50 = 570 nM); potentiates chemotherapeutic action; oxidized form of ansatrienin B

Ansatrienin A – 5 mg

Brand:
Cayman
CAS:
82189-03-5
Storage:
-20
UN-No:
Non-Hazardous - /

Ansatrienin A is an ansamycin antibiotic and antifungal agent first isolated from S. collinus and S. rishiriensis.{37029,37026} In fetal rat long bones, it is an inhibitor of parathyroid hormone-induced calcium release (IC50 = 64 nM), which is a measure of bone resorption, and pp60c-srcM kinase (IC50 = 100 nM).{37028} It also inhibits TNF-α-induced expression of intercellular adhesion molecule-1 (ICAM-1; IC50 = 570 nM).{37025} Early in vitro studies showed that ansatrienin A potentiates the chemotherapeutic action of 5-fluorouracil (Item No. 14416), cisplatin (Item No. 13119), bleomycin (Item No. 13877), mitomycin C (Item No. 11435), and 6-mercaptopurine.{37027} It is an oxidized form of ansatrienin B (Item No. 21996).{37026}  

 

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Description

An ansamycin antibiotic and antifungal; inhibits bone resorption (IC50 = 64 nM); inhibits pp60c-srcM kinase (IC50 = 100 nM); inhibits TNF-α-induced expression of ICAM-1 (IC50 = 570 nM); potentiates chemotherapeutic action; oxidized form of ansatrienin B

Formal name: N-(cyclohexylcarbonyl)-D-alanine (5R,6E,8E,10E,13S,14R,15R,16Z)-15-hydroxy-5-methoxy-14,16-dimethyl-3,22,24-trioxo-2-azabicyclo[18.3.1]tetracosa-6,8,10,16,20,23-hexaen-13-yl ester

Synonyms:  Mycotrienin I

Molecular weight: 636.8

CAS: 82189-03-5

Purity: ≥98%

Formulation: A powder

Product Type|Biochemicals|Antibiotics|Ansamycins||Product Type|Biochemicals|Antifungals||Product Type|Biochemicals|Kinase Inhibitors|SRC Family||Product Type|Biochemicals|Natural Products|Microbial Metabolites||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Signaling||Research Area|Endocrinology & Metabolism|Bone Growth & Remodeling||Research Area|Endocrinology & Metabolism|Hormones & Receptors|Thyroid Hormones||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases||Research Area|Infectious Disease|Fungal Diseases

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