A microtubule depolymerizing agent that binds tubulin (Kd = 1.3 µM)

Ansamitocin P-3 – 5 mg

Brand:
Cayman
CAS:
66547-09-9
Storage:
-20
UN-No:
Non-Hazardous - /

Ansamitocin P-3 is a microtubule depolymerizing agent that can be isolated from culture broths of certain Gram-positive bacteria.{32392,32391} It binds tubulin (Kd = 1.3 µM), depolymerizes microtubules in both interphase and mitosis, and perturbs chromosome segregation.{32393} Ansamitocin P-3 also activates the spindle checkpoint surveillance proteins Mad2 and BubR1, blocking cell cycling during mitosis.{32393} It inhibits the growth of cancer cells in culture and significantly suppresses the growth of several cancer tumors in mice, prolonging survival time.{32392,32393}  

 

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Description

A microtubule depolymerizing agent that binds tubulin (Kd = 1.3 µM), depolymerizes microtubules in both interphase and mitosis, and perturbs chromosome segregation

Formal name: 3-O-de[2-(acetylmethylamino)-1-oxopropyl]-3-O-(1-oxobutyl)-maytansine

Synonyms:  Antibiotic C-15003P3|Maytansinol butyrate

Molecular weight: 635.2

CAS: 66547-09-9

Purity: ≥85%

Formulation: A crystalline solid

Product Type|Biochemicals|Microtubule Dynamics||Product Type|Biochemicals|Natural Products|Microbial Metabolites||Product Type|Biochemicals|Small Molecule Activators||Research Area|Cancer|Cell Cycle|G2/M||Research Area|Cell Biology|Cell Cycle||Research Area|Cell Biology|Cytoskeleton & Motor Proteins

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