An inhibitor of ANO1 that blocks ATP-induced apical membrane chloride currents in ANO1-expressing FRT cells (IC50 = 77 nM); selective for ANO1 over ANO2 at 10 μM and CFTR and ENaC at 30 μM; inhibits ATP-induced quenching of a fluorescent intracellular halide sensor in PC3 prostate cancer cells and Capan-1 pancreatic carcinoma cells in a concentration-dependent manner

Ani 9 – 5 mg

Brand:
Cayman
CAS:
356102-14-2
Storage:
-20
UN-No:
Non-Hazardous - /

Ani 9 is an inhibitor of the calcium-activated chloride channel (CaCC) anoctamin 1 (ANO1) that blocks ATP-induced apical membrane chloride currents in ANO1-expressing Fischer rat thyroid (FRT) cells (IC50 = 77 nM).{53185} It is selective for ANO1 over ANO2 at 10 μM and the cystic fibrosis transmembrane conductance regulator (CFTR) and epithelial sodium channel (ENaC) at 30 μM. Ani 9 inhibits ATP-induced quenching of a fluorescent intracellular halide sensor in PC3 prostate cancer cells and Capan-1 pancreatic carcinoma cells in a concentration-dependent manner.  

 

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SKU: 29733 - 5 mg Category:

Description

An inhibitor of ANO1 that blocks ATP-induced apical membrane chloride currents in ANO1-expressing FRT cells (IC50 = 77 nM); selective for ANO1 over ANO2 at 10 μM and CFTR and ENaC at 30 μM; inhibits ATP-induced quenching of a fluorescent intracellular halide sensor in PC3 prostate cancer cells and Capan-1 pancreatic carcinoma cells in a concentration-dependent manner

Formal name: 2-(4-chloro-2-methylphenoxy)-acetic acid, 2-[(2-methoxyphenyl)methylene]hydrazide

Synonyms: 

Molecular weight: 332.8

CAS: 356102-14-2

Purity: ≥98%

Formulation: A solid

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