An agonist at AT1 and AT2 receptors

Angiotensin III (human, mouse) – 10 mg

Brand:
Cayman
CAS:
13602-53-4
Storage:
-20
UN-No:
Non-Hazardous - /

Angiotensin III (Ang III) is a heptapeptide agonist at the angiotensin 1 (AT1) and AT2 receptors, with a 30-fold higher affinity for AT2 compared with AT1 in HEK293 cells.{26232,34120} Ang III is the preferred agonist for renal AT2 receptors, which are responsible for sodium excretion into the urine.{34101} Ang III induces the same level of aldosterone synthesis as Ang II but has lower vasoconstrictive activity in vivo.{34099} In the brain renin-angiotensin system, Ang III increases sympathetic nerve activity and vasopressin release and dampens the baroreflex leading to higher blood pressure.{34100}  

 

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Description

An agonist at AT1 and AT2 receptors, with a 30-fold higher affinity for AT2

Formal name: 5-L-isoleucine-2-8-angiotensin II

Synonyms: 

Molecular weight: 931.1

CAS: 13602-53-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Peptides||Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Cardiovascular System|Cardiovascular Diseases|Hypertension||Research Area|Cardiovascular System|Kidney & Renal Disease||Research Area|Cardiovascular System|Vasculature|Vasoconstriction||Research Area|Endocrinology & Metabolism|Hormones & Receptors||Research Area|Neuroscience|Neuroendocrinology

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