A diterpenoid compound that inhibits NF-κB binding to DNA promoters and induces expression of the CYP1A enzymes to produce immunosuppressant

Andrographolide – 100 mg

Brand:
Cayman
CAS:
5508-58-7
Storage:
-20
UN-No:
Non-Hazardous - /

Andrographolide is a labdane diterpenoid that is the main bioactive component of A. paniculata, a well-recognized medicinal plant in Asia. It exerts a wide range of therapeutic actions, including immunosuppressant, antithrombotic, anti-inflammatory, antineoplastic, antiviral, antibacterial, antidiabetic, antioxidative stress, antipyretic, antioedematogenic, and antinociceptive activities.{21112} Andrographolide treatment inhibits nuclear factor kappa B (NF-κB) binding to DNA promoters of target genes (IC50 = ~15 μM), by forming a covalent adduct with reduced cysteine (62) of the NF-κB p50 subunit, and can also induce expression of the CYP1A subfamily of the cytochrome P450 family of enzymes.{21113,21111} At 5 μg/g body weight it can suppress the activation of NF-κB in stimulated endothelial cells, reducing the expression of the cell adhesion molecule E-selectin, abrogating the cytokine- and endotoxin-induced peritoneal infiltration of neutrophils, attenuating septic shock, and preventing allergic lung inflammation in a mouse model of asthma.{21111}  

 

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SKU: 11679 - 100 mg Category:

Description

A diterpenoid compound that inhibits NF-κB binding to DNA promoters and induces expression of the CYP1A enzymes to produce immunosuppressant, antithrombotic, anti-inflammatory, antineoplastic, antiviral, antibacterial, antidiabetic, antioxidative stress, antipyretic, antiedematogenic, and antinociceptive activities

Formal name: 3E-[2-[(1R,4aS,5R,6R,8aS)-decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-naphthalenyl]ethylidene]dihydro-4S-hydroxy-2(3H)-furanone

Synonyms: 

Molecular weight: 350.5

CAS: 5508-58-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antibiotics||Product Type|Biochemicals|Antivirals||Product Type|Biochemicals|Natural Products|Terpenes||Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Research Area|Cell Biology|Cell Signaling|NF-κB Signaling||Research Area|Epigenetics, Transcription, & Translation|Transcription Factors||Research Area|Immunology & Inflammation|Immunosuppressants||Research Area|Immunology & Inflammation|Innate Immunity|Sepsis/Shock||Research Area|Immunology & Inflammation|Pulmonary Diseases|Asthma||Research Area|Infectious Disease|Bacterial Diseases

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