A farnesyltransferase inhibitor; increases accumulation of chemotheraputic agents in drug resistant cancer cell culture (VJ-300)

Andrastin A – 500 µg

Brand:
Cayman
CAS:
174232-42-9
Storage:
-20
UN-No:
Non-Hazardous - /

Andrastin A is a meroterpenoid farnesyltransferase inhibitor.{39016} It increases the accumulation and effect of the chemotheraputic agent vincristine (sulfate) (Item No. 11764 in multidrug resistant VJ-300 cell culture (the IC50 of vincristine decreased 1.5-20-fold upon treatment with 6.25 μg/ml to 50 μg/ml of of andrastin A), most likely by binding to plasma membrane phosphoglycoprotein to prevent drug efflux.{39018} Andrastin A inhibits survival of Caco-2 cells with an IC50 of >50 μg/ml.{39017}  

 

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Description

A farnesyltransferase inhibitor; increases accumulation of chemotheraputic agents in drug resistant cancer cell culture (VJ-300),

Formal name: (3β,5β,8α,9β,10α,13α)-3β-(acetyloxy)-4,4,8,12,16-pentamethyl-15,17,19-trioxoandrost-11-ene-14-carboxylic acid, methyl ester

Synonyms:  NSC 697452

Molecular weight: 486.6

CAS: 174232-42-9

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Acyltransferases||Research Area|Cancer|Cell Death||Research Area|Cancer|Multidrug Resistance||Research Area|Lipid Biochemistry|Protein Lipidation

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