An internal standard for the quantification of anastrozole by GC- or LC-MS

Anastrozole-d12 – 1 mg

Brand:
Cayman
CAS:
120512-32-5
Storage:
-20
UN-No:
Non-Hazardous - /

Anastrozole-d12 is intended for use as an internal standard for the quantification of anastrozole (Item No. 11987) by GC- or LC-MS. Anastrozole is an aromatase/CYP19A1 inhibitor (IC50 = 15 nM for human placental aromatase/CYP19A1).{21405} It is selective for aromatase/CYP19A1 over the cytochrome P450 (CYP) isoforms CYP1A2, CYP2A6, CYP2C9, CYP2D6, and CYP3A (IC50s = 27-650 μM). Anastrozole (0.1 mg/kg) blocks ovulation in mature female rats and androstenedione-stimulated uterine development in pubertal female rats.{43283} It inhibits peripheral aromatase/CYP19A1 and reduces plasma estradiol concentrations in male pigtailed monkeys when administered at doses greater than 0.1 mg/kg. Anastrozole (0.5 mg/kg) reduces tumor incidence and the number of tumors by 40 and 57%, respectively, as well as increases latency to tumor appearance in a rat model of premenopausal mammary tumorigenesis.{43284} Formulations containing anastrozole have been used in the treatment of breast cancer.  

 

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SKU: 25360 - 1 mg Category:

Description

An internal standard for the quantification of anastrozole by GC- or LC-MS

Formal name: α,α,α’,α’-tetra(methyl-d3)-5-(1H-1,2,4-triazol-1-ylmethyl)-1,3-benzenediacetonitrile

Synonyms:  Anastrol-d12

Molecular weight: 305.4

CAS: 120512-32-5

Purity: ≥99% deuterated forms (d1-d12)

Formulation: A solid

Application|Mass Spectrometry||Product Type|Biochemicals|Analytical Standards||Product Type|Biochemicals|Isotopically Labeled Standards|Deuterium||Product Type|Biochemicals|Small Molecule Inhibitors|Cytochrome P450||Product Type|Biochemicals|Small Molecule Inhibitors|MMPs||Research Area|Cancer||Research Area|Endocrinology & Metabolism|Hormones & Receptors||Research Area|Endocrinology & Metabolism|Reproductive Biology

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