A small molecule agonist of GHS-R1a (Ki = 0.7 nM); induces calcium mobilization in CHO cells expressing rat GHS-R1a in a concentration-dependent manner and GH release from rat pituitary cells (EC50 = 1.5 nM); stimulates GH release in sham and vagotomized rats; increases food intake in rats

Anamorelin – 5 mg

Brand:
Cayman
CAS:
249921-19-5
Storage:
-20
UN-No:
Non-Hazardous - /

Anamorelin is a small molecule agonist of the growth hormone (GH) secretagogue receptor 1a (GHS-R1a) and a mimetic of ghrelin (Item Nos. 15072 | 24458; Ki = 0.7 nM).{41766,41767} It induces calcium mobilization in CHO cells expressing rat GHS-R1a in a concentration-dependent manner and GH release from rat pituitary cells (EC50 = 1.5 nM). In vivo, anamorelin stimulates GH release in sham and vagotomized rats in a dose-dependent manner.{41766} Anamorelin (3-30 mg/kg) also increases food intake in rats.{41767} Formulations containing anamorelin have been used to treat cancer anorexia and cachexia in patients with non-small cell lung cancer.  

 

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SKU: 24676 - 5 mg Category:

Description

A small molecule agonist of GHS-R1a (Ki = 0.7 nM); induces calcium mobilization in CHO cells expressing rat GHS-R1a in a concentration-dependent manner and GH release from rat pituitary cells (EC50 = 1.5 nM); stimulates GH release in sham and vagotomized rats; increases food intake in rats

Formal name: (3R)-1-[(2R)-2-[(2-amino-2-methyl-1-oxopropyl)amino]-3-(1H-indol-3-yl)-1-oxopropyl]-3-(phenylmethyl)-1,2,2-trimethylhydrazide, 3-piperidinecarboxylic acid

Synonyms:  RC-1291

Molecular weight: 546.7

CAS: 249921-19-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Cancer||Research Area|Endocrinology & Metabolism|Hormones & Receptors

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