An alkaloid with nematocidal and anticancer activities; binds to muscarinic and nicotinic AChRs (IC50s = 132 and 2

Anagyrine – 5 mg

Brand:
Cayman
CAS:
486-89-5
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

Anagyrine is an alkaloid that has been found in L. albus and has nematocidal and anticancer activities.{53991,53992,53415} It binds to muscarinic and nicotinic acetylcholine receptors (AChRs) with IC50 values of 132 and 2,096 µM, respectively, in radioligand binding assays using pig brain membranes that endogenously express high levels of the receptors.{53991} Anagyrine decreases survival of B. xylophilus worms.{53992} It inhibits proliferation of TE-671 and SH-SY5Y cancer cells (EC50s = 18.1 and 19.1 µM, respectively).{53415} Maternal ingestion of anagyrine during gestation is associated with the teratogenic condition crooked calf disease in cattle.{53993}  

 

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SKU: 31169 - 5 mg Category:

Description

An alkaloid with nematocidal and anticancer activities; binds to muscarinic and nicotinic AChRs (IC50s = 132 and 2,096 µM, respectively, in radioligand binding assays using pig brain membranes that endogenously express high levels of the receptors); decreases survival of B. xylophilus worms; inhibits proliferation of TE-671 and SH-SY5Y cancer cells (EC50s = 18.1 and 19.1 µM, respectively); maternal ingestion of anagyrine during gestation is associated with crooked calf disease in cattle

Formal name: (7R,14R,14aR)-1,3,4,6,7,13,14,14a-octahydro-7,14-methano-2H,11H-dipyrido[1,2-a:1′,2′-e][1,5]diazocin-11-one

Synonyms:  Monolupine

Molecular weight: 244.3

CAS: 486-89-5

Purity: ≥95%

Formulation: A solid

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