A 2-hydroxy-6-alkylbenzoic acid in which the alkyl chain contains 15 carbons and is unsaturated at the 8 position; inhibits SUMOylation in vitro (IC50 = 3 µM) and in cells without affecting protein ubiquitination; directly binds the SUMO-activating enzyme E1

Anacardic Acid monoene – 1 mg

Brand:
Cayman
CAS:
22910-60-7
Storage:
-20
UN-No:
Non-Hazardous - /

Extracts of the leaves and fruit of Ginkgo plants have long been used in traditional medicine and have multiple potential therapeutic applications, including ameliorating dementia.{29843,29842} However, ginkgolic acids, 2-hydroxy-6-alkylbenzoic acids related to anacardic acids, may be deleterious components in these extracts.{29843} Ginkgolic acid C15:1 is a 2-hydroxy-6-alkylbenzoic acid in which the alkyl chain contains 15 carbons and is unsaturated at the 8 position.{29843} It inhibits SUMOylation in vitro (IC50 = 3 µM) and in cells without affecting protein ubiquitination.{29841,29844} Ginkgolic acid C15:1 directly binds the SUMO-activating enzyme E1, blocking the formation of the E1-SUMO intermediate.{29841} Ginkgolic acid C15:1 also suppresses the development of pancreatic cancer xenografts in mice.{29845}  

 

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Description

A 2-hydroxy-6-alkylbenzoic acid in which the alkyl chain contains 15 carbons and is unsaturated at the 8 position; inhibits SUMOylation in vitro (IC50 = 3 µM) and in cells without affecting protein ubiquitination; directly binds the SUMO-activating enzyme E1, blocking the formation of the E1-SUMO intermediate

Formal name: 2-hydroxy-6-(8Z)-8-pentadecenyl-benzoic acid

Synonyms:  Anacardic Acid 15:1|Ginkgolic Acid I|Ginkogolic Acid C15:1

Molecular weight: 346.5

CAS: 22910-60-7

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Lipids||Product Type|Biochemicals|Natural Products||Research Area|Cancer||Research Area|Neuroscience|Behavioral Neuroscience|Learning & Memory

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