An alkyl salicylic acid isolated from cashew shells; inhibits the HAT activity of p300 and PCAF (IC50 = 8.5 and 5 µM

Anacardic Acid – 10 mg

Brand:
Cayman
CAS:
16611-84-0
Storage:
-20
UN-No:
Non-Hazardous - /

Anacardic acid, isolated from cashew shells or several other medicinal plants, is the general name given to a family of four different 6-alkyl salicyclic acids having varying degrees of unsaturation in the 15-carbon alkyl chain.{17761} These compounds are associated with anti-inflammatory, anti-tumor, molluscicidal, and anti-microbial activity. Literature frequently sites and gives the name anacardic acid to the completely-saturated compound (6-pentadecyl salicylic acid). Anacardic acid inhibits the histone acetyltransferase (HAT) activity of the transcription co-activators p300 and p300/CREB-binding protein-associated factor (PCAF) with IC50 values of 8.5 and 5 µM, respectively.{17763} At 25 µmol/L, anacardic acid suppresses NF-κB activation, inhibits IκB-α phosphorylation, and prohibits p65 nuclear translocation in KBM-5 cells.{17762}  

 

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Description

An alkyl salicylic acid isolated from cashew shells; inhibits the HAT activity of p300 and PCAF (IC50 = 8.5 and 5 µM, respectively); suppresses NF-κB activation, inhibits IκBα phosphorylation, and prohibits p65 nuclear translocation

Formal name: 2-hydroxy-6-pentadecyl-benzoic acid

Synonyms:  6-pentadecyl Salicylic Acid

Molecular weight: 348.5

CAS: 16611-84-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Lipids||Product Type|Biochemicals|Small Molecule Inhibitors|Acyltransferases||Research Area|Cell Biology|Cell Signaling|NF-κB Signaling||Research Area|Epigenetics, Transcription, & Translation|Readers|Bromodomains||Research Area|Epigenetics, Transcription, & Translation|Transcription Factors||Research Area|Epigenetics, Transcription, & Translation|Writers|Histone Acetylation||Research Area|Immunology & Inflammation

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