A TrkB receptor antagonist that prevents activation of the receptor by BDNF (IC50s = 45.6 nM and 41.1 μM for the high and low affinity sites of the receptor

ANA-12 – 1 mg

Brand:
Cayman
CAS:
219766-25-3
Storage:
-20
UN-No:
Non-Hazardous - /

ANA-12 is a TrkB receptor antagonist that prevents activation of the receptor by BDNF with IC50 values of 45.6 nM and 41.1 μM for the high and low affinity sites of the receptor, respectively.{32046} It does not affect TrkA or TrkC in an assay of neurite outgrowth.{32046} Mice administered ANA-12 demonstrated reduced anxiety- and depression-related behaviors on a variety of tests predictive of anxiolytic and antidepressant properties in humans.{32046}  

 

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Description

A TrkB receptor antagonist that prevents activation of the receptor by BDNF (IC50s = 45.6 nM and 41.1 μM for the high and low affinity sites of the receptor, respectively); demonstrates antianxiety and antidepressant properties in mouse models

Formal name: N-[2-[[(hexahydro-2-oxo-1H-azepin-3-yl)amino]carbonyl]phenyl]-benzo[b]thiophene-2-carboxamide

Synonyms: 

Molecular weight: 407.5

CAS: 219766-25-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|Other Receptor Tyrosine Kinases||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Neuroscience|Behavioral Neuroscience|Anxiety||Research Area|Neuroscience|Behavioral Neuroscience|Depression

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