A potent and selective bacterial leucyl-tRNA synthetase inhibitor; active against strains of Enterobacteriaceae (MIC50/90 = 0.5/1 µg/ml) and the non-fermentative Gram-negative clinical isolates P. aeruginosa

AN3365 (hydrochloride) – 5 mg

Brand:
Cayman
CAS:
1234563-16-6
Storage:
-20
UN-No:
Non-Hazardous - /

AN3365 (hydrochloride) is a potent and selective bacterial leucyl-tRNA synthetase inhibitor active against Gram-negative bacteria.{34087} It is a member of a novel class of boron-containing compounds, the aminomethyl benzoxoaboroles, that have potential to combat multidrug resistance.{34086} It is active against many microbial strains, including strains of Enterobacteriaceae (MIC50/90 = 0.5/1 µg/ml) and the non-fermentative Gram-negative clinical isolates P. aeruginosa, A. baumannii, S. maltophilia, and B. cepacid (MIC50/90s = 4/8, 4/8, 2/4, and 8/32 µg/ml, respectively).{34087} However, in a Phase II clinical trial for complicated urinary tract infections, bacterial resistance occurred very rapidly and the study was terminated.{34088}  

 

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Description

A potent and selective bacterial leucyl-tRNA synthetase inhibitor; active against strains of Enterobacteriaceae (MIC50/90 = 0.5/1 µg/ml) and the non-fermentative Gram-negative clinical isolates P. aeruginosa, A. baumannii, S. maltophilia, and B. cepacid (MIC50/90s = 4/8, 4/8, 2/4, and 8/32 µg/ml, respectively); bacterial resistance led to termination of a Phase II clinical trial,

Formal name: 3-[[(3S)-3-(aminomethyl)-1,3-dihydro-1-hydroxy-2,1-benzoxaborol-7-yl]oxy]-1-propanol, monohydrochloride

Synonyms:  Epetraborole|GSK2251052

Molecular weight: 273.5

CAS: 1234563-16-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antibiotics||Product Type|Biochemicals|Small Molecule Inhibitors|MMPs||Product Type|Biochemicals|Small Molecule Inhibitors|Nucleic Acid Turnover/Signaling||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases

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