A selective PDE4 inhibitor (IC50 = 0.11 µM); suppresses the release of the proinflammatory cytokines TNF-α

AN2728 – 25 mg

Brand:
Cayman
CAS:
906673-24-3
Storage:
-20
UN-No:
Non-Hazardous - /

AN2728 is a boron-based, topical anti-inflammatory agent that inhibits phosphodiesterase 4 (PDE4; IC50 = 0.11 µM).{33611} It is less potent against PDE1A, PDE3A, and PDE7A (IC50s = 6.12, 6.41, and 0.73 µM, respectively).{33611} AN2728 suppresses the release of the proinflammatory cytokines TNF-α, IL-2, INF-γ, IL-5, and IL-10 with IC50 values of 0.50, 0.59, 0.72, 2.25, and 2.58 µM, respectively.{33611}  

 

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Description

A selective PDE4 inhibitor (IC50 = 0.11 µM); suppresses the release of the proinflammatory cytokines TNF-α, IL-2, INF-γ, IL-5, and IL-10 (IC50s = 0.50, 0.59, 0.72, 2.25, and 2.58 µM, respectively)

Formal name: 4-[(1,3-dihydro-1-hydroxy-2,1-benzoxaborol-5-yl)oxy]-benzonitrile

Synonyms:  Crisaborole

Molecular weight: 251.1

CAS: 906673-24-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Phosphodiesterases||Research Area|Immunology & Inflammation

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