A glycoside with diverse biological activities; induces cell cycle arrest at the G0/G1 phase

Amygdalin – 25 g

Brand:
Cayman
CAS:
29883-15-6
Storage:
4
UN-No:
Non-Hazardous - /

Amygdalin is a cyanogenic glycoside that has been found in seeds from plants of the Rosaceae family and has diverse biological activities.{47285,47286,47287,47288,47289} It induces cell cycle arrest at the G0/G1 phase, decreases cyclin A and Cdk2 levels, and inhibits cell growth in UMUC-3, RT112, and TCCSUP bladder cancer cells when used at concentrations ranging from 1.25 to 10 mg/ml.{47286} Amygdalin (3 mg/kg) reduces the number of primary microtubules and microvessels in aortic rings isolated from rats with diabetes induced by streptozotocin (Item No. 13104).{47287} In vivo, amygdalin reduces triglyceride, total cholesterol, and LDL levels and aortic sinus plaque area in an LDLR-/- mouse model of atherosclerosis.{47288} It also reduces production of TNF-α, IL-1β, and IL-6, as well as neutrophil and macrophage infiltration, in bronchoalveolar lavage fluid (BALF) in a mouse model of LPS-induced acute lung injury.{47289}  

 

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SKU: 26668 - 25 g Category:

Description

A glycoside with diverse biological activities; induces cell cycle arrest at the G0/G1 phase, decreases cyclin A and Cdk2 levels, and inhibits cell growth in UMUC-3, RT112, and TCCSUP bladder cancer cells from 1.25-10 mg/ml; reduces the number of primary microtubules and microvessels in aortic rings isolated from rats with streptozotocin-induced diabetes at 3 mg/kg; reduces triglyceride, total cholesterol, and LDL levels and aortic sinus plaque area in an LDLR-/- mouse model of atherosclerosis; reduces production of TNF-α, IL-1β, and IL-6 as well as neutrophil and macrophage infiltration in BALF in a mouse model of LPS-induced acute lung injury

Formal name: αR-[(6-O-β-D-glucopyranosyl-β-D-glucopyranosyl)oxy]-benzeneacetonitrile

Synonyms:  (–)-Amygdalin|(D)-Amygdalin|(R)-Amygdalin|Amygdaloside|NSC 15780

Molecular weight: 457.4

CAS: 29883-15-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Glycosides||Research Area|Cancer|Cell Cycle|G1||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Dyslipidemias||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Immunology & Inflammation|Pulmonary Diseases

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