A TRPM8 antagonist; inhibits calcium influx induced by the TRPM8 agonist icilin (IC50 = 0.58 µM); decreases the visceromotor reflex response to urinary bladder distension (ID50 = 2.42 mg/kg); an inhibitor of Nav1.1-1.8 (IC50s = 2-14.8 µM); decreases viability of MDA-MB-231 and SK-BR-3 breast cancer cells (IC50s = ~23.7 and 17.3 µM

AMTB – 1 mg

Brand:
Cayman
CAS:
926023-82-7
Storage:
-20
UN-No:
Non-Hazardous - /

AMTB is an antagonist of transient receptor potential melastatin 8 (TRPM8).{37683} It inhibits calcium influx induced by the TRPM8 agonist icilin (Item No. 10137) with an IC50 value of 0.58 µM. AMTB (3 mg/kg) decreases the number of volume-induced bladder contractions in a rat model of noxious bladder distension. It also decreases the visceromotor reflex response to urinary bladder distension (ID50 = 2.42 mg/kg), indicating antinociceptive activity. AMTB inhibits the sodium channel (Nav) isoforms Nav1.1-1.8 (IC50s = 2-14.8 µM) and decreases viability of MDA-MB-231 and SK-BR-3 breast cancer cells (IC50s = ~23.7 and 17.3 µM, respectively) in a TRPM8-independent manner.{37684}  

 

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Description

A TRPM8 antagonist; inhibits calcium influx induced by the TRPM8 agonist icilin (IC50 = 0.58 µM); decreases the visceromotor reflex response to urinary bladder distension (ID50 = 2.42 mg/kg); an inhibitor of Nav1.1-1.8 (IC50s = 2-14.8 µM); decreases viability of MDA-MB-231 and SK-BR-3 breast cancer cells (IC50s = ~23.7 and 17.3 µM, respectively) in a TRPM8-independent manner

Formal name: N-(3-aminopropyl)-2-[(3-methylphenyl)methoxy]-N-(2-thienylmethyl)-benzamide, monohydrochloride

Synonyms: 

Molecular weight: 431

CAS: 926023-82-7

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Ion Channel Modulation|Blockers||Research Area|Cancer|Cell Death||Research Area|Neuroscience|Pain Research

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