A topoisomerase II poison; stimulates formation of a complex between DNA and topoisomerase II in which the DNA is cleaved and topoisomerase II remains covalently linked to the 5’ end of the DNA cleavage products; inhibits the DNA strand-passing activity of topoisomerase II at a concentration of 20 μg/ml; reduces growth of LoVo human colorrectal carcinoma and T1 human lymphoma cells in a dose-dependent manner; antitumor activity against several murine leukemia

Amsacrine (hydrochloride) – 10 mg

Brand:
Cayman
CAS:
54301-15-4
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

Amsacrine is a topoisomerase II poison.{41155} It stimulates formation of a complex between DNA and topoisomerase II in which the DNA is cleaved and topoisomerase II remains covalently linked to the 5’ end of the DNA cleavage products. Amsacrine also inhibits the DNA strand-passing activity of topoisomerase II at a concentration of 20 μg/ml. It reduces growth of LoVo human colorectal carcinoma and T1 human lymphoma cells in a dose-dependent manner and this effect is 10-fold more potent in proliferating cells compared to non-proliferating cells.{41156} Amsacrine has antitumor activity against several murine leukemia, melanoma, lung, colon, and mammary xenograft mouse models.{41157}  

 

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Description

A topoisomerase II poison; stimulates formation of a complex between DNA and topoisomerase II in which the DNA is cleaved and topoisomerase II remains covalently linked to the 5’ end of the DNA cleavage products; inhibits the DNA strand-passing activity of topoisomerase II at a concentration of 20 μg/ml; reduces growth of LoVo human colorrectal carcinoma and T1 human lymphoma cells in a dose-dependent manner; antitumor activity against several murine leukemia, melanoma, lung, colon, and mammary xenograft mouse models

Formal name: N-[4-(9-acridinylamino)-3-methoxyphenyl]-methanesulfonamide, monohydrochloride

Synonyms:  m-AMSA|AMSA|NSC 141549

Molecular weight: 429.9

CAS: 54301-15-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Topoisomerases||Research Area|Cancer|DNA Damage and Repair|Topoisomerase

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