A thiamine analog and antiprotozoal agent that interferes with thiamine metabolism and inhibits carbohydrate synthesis; competitively inhibits thiamine uptake by E. tenella schizonts and by chick host intestinal cells (Kis = 7.6 and 326 μM

Amprolium (hydrochloride) – 25 g

Brand:
Cayman
CAS:
137-88-2
Storage:
4
UN-No:
Non-Hazardous - /

Amprolium is a thiamine analog and antiprotozoal agent that interferes with thiamine metabolism and inhibits carbohydrate synthesis.{39908,39909,39910,39911} It competitively inhibits thiamine uptake by E. tenella schizonts and by chick host intestinal cells (Kis = 7.6 and 326 μM, respectively).{39908} It also inhibits hexose formation and pentose utilization ex vivo in isolated lysed rat erythrocytes and in liver, kidney, heart, and intestinal tissue homogenates following dietary administration.{39909} Amprolium (1,000 ppm in feed) inhibits oocyst output and sporulation of Eimeria maxima, E. brunetti, and E. acervulina in infected chicks.{39910} It also decreases lesion and oocyst scores and mortality of E. tenella-infected chicks following dietary administration of a 125 ppm dose.{39911} Amprolium (100 μM) induces apoptosis in PC12 rat adrenal cells and increases the level of cleaved caspase-3.{39912} Formulations containing amprolium have been used as coccidiostats in poultry processing.  

 

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SKU: 25506 - 25 g Category:

Description

A thiamine analog and antiprotozoal agent that interferes with thiamine metabolism and inhibits carbohydrate synthesis; competitively inhibits thiamine uptake by E. tenella schizonts and by chick host intestinal cells (Kis = 7.6 and 326 μM, respectively); inhibits hexose formation and pentose utilization ex vivo in isolated lysed rat erythrocytes and in liver, kidney, heart, and intestinal tissue homogenates following dietary administration; inhibits oocyst output and sporulation of Eimeria maxima, E. brunetti, and E. acervulina in infected chicks at 1,000 ppm in the diet; decreases lesion and oocyst scores and mortality of E. tenella-infected chicks at 125 ppm in the diet; induces apoptosis in PC12 rat adrenal cells and increases the level of cleaved caspase-3 at 100 μM

Formal name: 1-[(4-amino-2-propyl-5-pyrimidinyl)methyl]-2-methyl-pyridinium, monochloride, monohydrochloride

Synonyms: 

Molecular weight: 315.2

CAS: 137-88-2

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antiparasitics|Antiprotozoals||Research Area|Cell Biology|Cell Death|Apoptosis||Research Area|Cell Biology|Proteolysis|Cytosolic & Secreted Proteases||Research Area|Endocrinology & Metabolism|Carbohydrate Metabolism||Research Area|Endocrinology & Metabolism|Cofactors & Vitamins||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Parasitic Diseases

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