An indirect activator of AMPK (EC50 = 11.7 μM); stimulates glucose uptake in L6 myocytes and promotes phosphorylation of ACC

AMPK activator – 1 mg

Brand:
Cayman
CAS:
849727-81-7
Storage:
-20
UN-No:
Non-Hazardous - /

AMPK activator is an indirect activator of AMP-activated protein kinase, AMPK (EC50 = 11.7 μM).{23464} It is thought to activate AMPK by inhibiting mitochondrial complex I, producing an increase in AMP levels.{23464} AMPK activator stimulates glucose uptake in L6 myocytes and promotes phosphorylation of acetyl-CoA carboxylase, a known target of AMPK.{23464} AMPK activator also decreases blood glucose concentrations in female Zucker diabetic rats, demonstrating its utility in whole animals.{23464} At 50 μM, it inhibits the growth of multiple myeloma cells.{23463} AMPK activator induces phosphorylation of raptor in PC3 prostate cancer cells, down-regulating mTORC1 signaling and reducing survivin expression.{23465}  

 

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Description

An indirect activator of AMPK (EC50 = 11.7 μM); stimulates glucose uptake in L6 myocytes and promotes phosphorylation of ACC, a known target of AMPK; decreases blood glucose concentrations in Zucker diabetic rats, demonstrating its utility in whole animals; inhibits the growth of multiple myeloma cells

Formal name: 5-[3-[4-[2-(4-fluorophenyl)ethoxy]phenyl]propyl]-2-furancarboxylic acid

Synonyms:  D942

Molecular weight: 368.4

CAS: 849727-81-7

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Activators|Kinases||Research Area|Cancer|Cell Signaling|PI3K/Akt/mTOR Signaling||Research Area|Cancer|Metabolism||Research Area|Cell Biology|Mitochondrial Biology||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes||Research Area|Endocrinology & Metabolism|Nutrient Sensing

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