A polyene macrolide used in the treatment of infections caused by C. albicans

Amphotericin B – 5 g

Brand:
Cayman
CAS:
1397-89-3
Storage:
-20
UN-No:
Non-Hazardous - /

Amphotericin B is a classic antifungal polyene macrolide that has been used in the treatment of systemic fungal infections, primarily caused by C. albicans, A. fumigatus, and parasitic L. protozoans, as well as in tissue culture to prevent fungi from contaminating cell cultures.{20815,20812,20813} Amphotericin B binds with ergosterol, the main component of fungal cell membranes, forming a transmembrane channel that results in altered plasma membrane permeability and leakage of vital cytoplasmic components, such as K+, ultimately inducing cell death.{20814} Because prolonged use of amphotericin B is associated with infusion-related events and nephrotoxicity, lipid-based formulations have been devised for more favorable clinical relevance.{20815,20812}  

 

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SKU: 11636 - 5 g Category:

Description

A polyene macrolide used in the treatment of infections caused by C. albicans, A. fumigatus, and parasitic L. protozoans, as well as in tissue culture to prevent fungi from contaminating cell cultures; binds with ergosterol in fungal cell membranes, altering membrane permeability and ultimately inducing cell death

Formal name: (1R,3S,5R,6R,9R,11R,15S,16R,17R,18S,19E,21E,23E,25E,27E,29E,31E,33R,35S,36R,37S)-33-[(3-amino-3,6-dideoxy-β-D-mannopyranosyl)oxy]-1,3,5,6,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-14,39-dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylic acid

Synonyms:  Abelcet®|AmBisome®|Ampho-Moronal®|Amphocin®|Amphozone®|Fungilin®|Fungizone®|Halizon®|LNS-AmB|NSC 527017

Molecular weight: 924.1

CAS: 1397-89-3

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Antifungals|Polyenes||Product Type|Biochemicals|Antiparasitics|Antiprotozoals||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Fungal Diseases|Aspergillosis||Research Area|Infectious Disease|Fungal Diseases|Candidiasis||Research Area|Infectious Disease|Parasitic Diseases

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