An antibacterial lipopeptide that targets Gram-positive bacteria and may be useful against drug resistant strains; also inhibits peptidoglycan synthesis

Amphomycin – 1 mg

Brand:
Cayman
CAS:
1402-82-0
Storage:
-20
UN-No:
Non-Hazardous - /

Amphomycin is a natural antibacterial lipopeptide first isolated from S. canus. Lipopeptides are cyclic depsipeptides with a peptidyl side chain capped with a saturated alkyl tail.{27765} They preferentially target Gram-positive bacteria and may be useful against drug resistant strains.{27765} Amphomycin is also an inhibitor of peptidoglycan synthesis in both bacterial and mammalian systems, as it binds with phosphorylated substrates in a calcium-dependent manner.{27780,27781,27782,27779}  

 

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Description

An antibacterial lipopeptide that targets Gram-positive bacteria and may be useful against drug resistant strains; also inhibits peptidoglycan synthesis

Formal name: 2,2′-((6S,9R,15S,21S,24S,26aR,33S,34R,36aS)-9-((R)-1-aminoethyl)-33-((2S)-3-carboxy-2-((Z)-10-methyldodec-3-enamido)propanamido)-24-((S)-1-carboxyethyl)-6-isopropyl-34-methyl-5,8,11,14,17,20,23,26,32,36-decaoxotetratriacontahydro-1H,5H-pyrido[1,2-a]pyrrolo[1,2-y][1,4,7,10,13,16,19,22,25,28]decaazacyclohentriacontine-15,21-diyl)diacetic acid

Synonyms: 

Molecular weight: 1,290.40

CAS: 1402-82-0

Purity: ≥95%

Formulation: An off-white to fawn solid

Product Type|Biochemicals|Antibiotics|Polypeptides||Product Type|Biochemicals|Natural Products||Research Area|Endocrinology & Metabolism|Carbohydrate Metabolism||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases

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