A hydrophobic derivative of deoxynojirimycin that potently inhibits β-glucosidase 2 (IC50 = 0.3 nM)

AMP-Deoxynojirimycin – 5 mg

Brand:
Cayman
CAS:
216758-20-2
Storage:
-20
UN-No:
De Minimis - 1170 / 3

The lipid messenger ceramide is converted to glucosylceramide by glucosylceramide synthase (GCS). In the reverse direction, non-lysosomal glucosylceramidase (GCase), also known as β-glucosidase 2 (BGD),{16474} cleaves the glucosyl moiety from glucosylceramide, liberating ceramide, which can be converted into sphingomyelin.{16472} AMP-deoxynojirimycin (AMP-dNM) is a hydrophobic derivative of dNM. It potently inhibits BGD (IC50 = 0.3 nM),{14948} less potently antagonizes GCS (IC50 = 25 nM),{16472} but only poorly inhibits other GCase isoforms. AMP-dNM has been shown to strongly suppress inflammation in a murine model of hapten-induced colitis,{16473} enhance insulin sensitivity in murine and rat models of insulin resistance,{14949} and induce sterol regulatory element-binding protein-regulated gene expression and cholesterol synthesis in HepG2 cells.{16474}  

 

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SKU: 10010332 - 5 mg Category:

Description

A hydrophobic derivative of deoxynojirimycin that potently inhibits β-glucosidase 2 (IC50 = 0.3 nM), less potently antagonizes glucosylceramide synthase (IC50 = 25 nM), but only poorly inhibits other GCase isoforms; suppresses hapten-induced colitis, enhances insulin sensitivity, and induces SREBP-regulated gene expression and cholesterol synthesis.

Formal name: 2R-(hydroxymethyl)-1-[5-(tricyclo[3.3.2.13,7]dec-1-ylmethoxy)pentyl]-3R,4R,5S-piperidinetriol

Synonyms:  Adamantane-pentyl-dNM|AMP-dNM|N-(5-adamantane-1-yl-methoxy-pentyl)-Deoxynojirimycin

Molecular weight: 397.6

CAS: 216758-20-2

Purity: ≥95%

Formulation: A solution in ethanol

Product Type|Biochemicals|Small Molecule Inhibitors|Sphingolipid Turnover||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes||Research Area|Immunology & Inflammation|Gastric Disease|Crohn’s Disease||Research Area|Immunology & Inflammation|Gastric Disease|Ulcerative Colitis

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