A semisynthetic β-lactam antibiotic; inhibits the growth of 30 isolates of P. mirabilis and 89% of 30 E. coli strains at ≥5 and 10 µg/ml

Amoxicillin (hydrate) – 25 g

Brand:
Cayman
CAS:
61336-70-7
Storage:
22
UN-No:
Non-Hazardous - /

Amoxicillin is an orally bioavailable, semisynthetic β-lactam antibiotic.{42429} It inhibits the growth of 30 isolates of P. mirabilis and 89% of 30 E. coli strains when used at concentrations greater than or equal to 5 and 10 µg/ml, respectively, but resistance develops in strains of Klebsiella, Enterobacter, and indole-positive Proteus species.{31108} Amoxicillin is susceptible to bacterial β-lactamases but is active against β-lactamase-producing bacteria when used in combination with β-lactamase antibiotics such as clavulanic acid with MIC values of greater than 4,096 and 16 µg/ml without or with clavulanic acid, respectively, against 46 clinical isolates of β-lactamase-producing E. coli.{42429} Formulations containing amoxicillin have been used in the treatment of a variety of bacterial infections.  

 

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Description

A semisynthetic β-lactam antibiotic; inhibits the growth of 30 isolates of P. mirabilis and 89% of 30 E. coli strains at ≥5 and 10 µg/ml, respectively; susceptible to bacterial β-lactamases, which leads to resistance; active against β-lactamase-producing bacteria when used in combination with β-lactamase antibiotics such as clavulanic acid; inhibits growth of β-lactamase-producing E. coli when used in combination with clavulanic acid (MICs = 4,096 and 16 µg/ml without or with clavulanic acid, respectively)

Formal name: (2S,5R,6R)-6-[[(2R)-2-amino-2-(4-hydroxyphenyl)acetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, trihydrate

Synonyms: 

Molecular weight: 419.4

CAS: 61336-70-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antibiotics|Penicillins||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases

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