A tetracyclic antidepressant that inhibits norepinephrine and serotonin reuptake

Amoxapine – 250 mg

Brand:
Cayman
CAS:
14028-44-5
Storage:
-20
UN-No:
Non-Hazardous - /

Amoxapine is a tetracyclic antidepressant with a wide range of pharmacological effects. It inhibits norepinephrine and serotonin reuptake, binding the respective transporters with Kd values of 16 and 58 nM.{22877} It has also been shown to act as either an antagonist or inverse agonist at serotonin 5-HT2A, 2B, 2C, 3, 6, 7 (Kis = 1 and 2 nM for 5-HT2A and 5-HT2C, respectively), dopamine D2, 3, 4 (Kd = 160 nM for D2), α1-adrenergic (Kd = 50 nM), and histamine H1 (Kd = 25 nM) receptors.{25805,25914}  

 

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Description

A tetracyclic antidepressant that inhibits norepinephrine and serotonin reuptake, binding the respective transporters with Kd values of 16 and 58 nM; acts as either an antagonist or inverse agonist at 5-HT2A, 2B, 2C, 3, 6, 7 (Kis = 1 and 2 nM for 5-HT2A and 5-HT2C), D2, 3, 4 (Kd = 160 nM for D2), α1-adrenergic (Kd = 50 nM), and H1 (Kd = 25 nM) receptors

Formal name: 2-chloro-11-(1-piperazinyl)-dibenz[b,f][1,4]oxazepine

Synonyms:  CL-67772

Molecular weight: 313.8

CAS: 14028-44-5

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Ion Channel Modulation||Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Product Type|Biochemicals|Receptor Pharmacology|Inverse Agonists||Product Type|Biochemicals|Transporter & Exchanger Modulators||Research Area|Neuroscience|Behavioral Neuroscience|Depression

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