A PPARγ agonist (Ki = 19 nM; EC50 = 73 nM) that was first isolated from A. fruticosa; 100 mg/kg/day improves insulin sensitivity

Amorfrutin B – 500 µg

Brand:
Cayman
CAS:
78916-42-4
Storage:
-20
UN-No:
Non-Hazardous - /

Amorfrutin B is a partial agonist of the peroxisome proliferator-activated receptor γ (PPARγ; Ki = 19 nM and EC50 = 73 nM) that was first isolated from A. fruticosa.{31276} It binds to PPARα and PPARβ/δ with Ki values of 2.6 and 1.7 µM, respectively.{31276} In insulin-resistant mice, 100 mg/kg/day amorfrutin B is reported to improve insulin sensitivity, glucose tolerance, and plasma lipid concentrations after two weeks of treatment.{31276}  

 

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Description

A PPARγ agonist (Ki = 19 nM; EC50 = 73 nM) that was first isolated from A. fruticosa; 100 mg/kg/day improves insulin sensitivity, glucose tolerance, and plasma lipid concentrations after two weeks of treatment in insulin-resistant mice

Formal name: 3-[(2E)-3,7-dimethyl-2,6-octadien-1-yl]-2-hydroxy-4-methoxy-6-(2-phenylethyl)-benzoic acid

Synonyms: 

Molecular weight: 408.5

CAS: 78916-42-4

Purity: ≥97%

Formulation: A solid

Product Type|Biochemicals|Natural Products||Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Endocrinology & Metabolism|Hormones & Receptors|PPARs||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Dyslipidemias

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