An antidiabetic natural product that binds to and activates PPARγ (Ki = 0.236 µM; EC50 = 0.458 µM); inhibits TNF-α-induced expression of inflammatory genes through both NF-κB and PPARγ activity with efficacy at 5-20 µM

Amorfrutin A – 500 µg

Brand:
Cayman
CAS:
80489-90-3
Storage:
-20
UN-No:
Non-Hazardous - /

Amorfrutin A is an isoprenoid-substituted benzoic acid natural product found in the fruit of A. fruticosa and G. foetida that exhibits antidiabetic effects. It binds to PPARγ with a Ki of 0.236 µM and activates a PPARγ gene reporter assay with an EC50 value of 0.458 µM.{34269} In high-fat diet-induced obese (DIO) mice, amorfrutin A (100 mg/kg/day) enhanced glucose tolerance and insulin sensitivity, while decreasing plasma triglycerides, free fatty acids, insulin, and glucose concentrations.{34269} Amorfrutin A inhibits TNF-α-induced expression of a number of inflammatory genes such as COX-2, IL-1β, MCP-1, MIP-2, MIP-3α, MMP-9, and IL-8 through inhibition of both NF-κB and PPARγ activity with efficacy at 5-20 µM.{34270,32801}  

 

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Description

An antidiabetic natural product that binds to and activates PPARγ (Ki = 0.236 µM; EC50 = 0.458 µM); inhibits TNF-α-induced expression of inflammatory genes through both NF-κB and PPARγ activity with efficacy at 5-20 µM

Formal name: 2-hydroxy-4-methoxy-3-(3-methyl-2-buten-1-yl)-6-(2-phenylethyl)-benzoic acid

Synonyms:  Amorfrutin 1

Molecular weight: 340.4

CAS: 80489-90-3

Purity: ≥97%

Formulation: A solid

Product Type|Biochemicals|Natural Products||Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Endocrinology & Metabolism|Hormones & Receptors|PPARs||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Dyslipidemias||Research Area|Immunology & Inflammation

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