An internal standard for the quantification of amlodipine by GC- or LC-MS

Amlodipine-d4 (maleate) – 1 mg

Brand:
Cayman
CAS:
1185246-15-4
Storage:
-20
UN-No:
Non-Hazardous - /

Amlodipine-d4 is intended for use as an internal standard for the quantification of amlodipine (Item No. 14838) by GC- or LC-MS. Amlodipine is a dihydropyridine L-type calcium channel blocker that selectively inhibits calcium influx in cardiac and vascular smooth muscle.{23674} Acting as a vasodilator, amlodipine reduces blood pressure by relaxing the smooth muscle in the arterial wall, decreasing total peripheral resistance. It inhibits calcium-induced contractions in depolarized rat aorta with an IC50 value of 1.9 nM, displaying a slow rate of association and dissociation in isolated vascular and cardiac tissues.{23674} Amlodipine also demonstrates actions independent of L-type calcium channel blockade by regulating membrane fluidity and cholesterol deposition, stimulating nitric oxide production, acting as an antioxidant, and regulating matrix deposition in vitro and in vivo.{23673} Formulations containing amlodipine have been used in the treatment of hypertension.  

 

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SKU: 25035 - 1 mg Category:

Description

An internal standard for the quantification of amlodipine by GC- or LC-MS,

Formal name: 3-ethyl 5-methyl 2-((2-aminoethoxy-1,1,2,2-d4)methyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate monomaleate

Synonyms: 

Molecular weight: 529

CAS: 1185246-15-4

Purity: ≥99% deuterated forms (d1-d4)

Formulation: A solid

Application|Mass Spectrometry||Product Type|Biochemicals|Analytical Standards||Product Type|Biochemicals|Ion Channel Modulation|Blockers||Product Type|Biochemicals|Isotopically Labeled Standards|Deuterium||Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Research Area|Cardiovascular System|Cardiovascular Diseases|Hypertension||Research Area|Cardiovascular System|Vasculature|Smooth Muscle Cells||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity

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