An anti-inflammatory and anti-allergic compound which is useful in the amelioration of aphthous ulcers

Amlexanox – 1 g

Brand:
Cayman
CAS:
68302-57-8
Storage:
-20
UN-No:
Non-Hazardous - /

Amlexanox is an anti-inflammatory and anti-allergic compound which is useful in the amelioration of aphthous ulcers (canker sores), commonly used as a 5% topical oral paste.{22218,22215} By way of mechanism of action, amlexanox associates with the calcium-binding proteins S100A12 and S100A13, inhibits the release of FGF1, and, at 1 mM, induces changes in the actin cytoskeleton.{22216,22217} More recently, amlexanox has been found to inhibit the non-canonical IKK-ε and TANK-binding kinase 1.{22219}  

 

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Description

An anti-inflammatory and anti-allergic compound which is useful in the amelioration of aphthous ulcers, commonly used as a 5% topical oral paste; associates with the calcium-binding proteins S100A12 and S100A13, inhibits the release of FGF1, and, at 1 mM, induces changes in the actin cytoskeleton

Formal name: 2-amino-7-(1-methylethyl)5-oxo-5H-[1]benzopyrano[2,3-b]pyridine-3-carboxylic acid

Synonyms:  AA 673|CHX 3673|Elics

Molecular weight: 298.3

CAS: 68302-57-8

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|IKKs||Product Type|Biochemicals|Kinase Inhibitors|Other Serine/Threonine Kinases||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Immunology & Inflammation|Allergy||Research Area|Immunology & Inflammation|Autoimmunity||Research Area|Immunology & Inflammation|Innate Immunity|Pattern Recognition||Research Area|Immunology & Inflammation|Innate Immunity|STING||Research Area|Infectious Disease

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